Visual cafe expert edition 4.0

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    (1988) showed that murine Dnmt cDNA encodes a C-terminal domain of 500 amino acids that is closely related to the bacterial type II restriction methyltransferases that form 5-methylcytosine. This catalytic domain is linked to an N-terminal domain of 1,000 amino acids that was predicted by Bestor (1990) to have regulatory functions. El-Deiry et al. (1991) cloned a portion of the human DNA methyltransferase gene. Expression of the gene was low in normal human cells, increased significantly in virally transformed cells, and was elevated in human cancer cells. The increases paralleled.

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