Garminmobilextforsymbians603rdedition 50050

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    The mycoplasma antigen MAM can activate T cells. MAM contains two domains, one of which can inhibit lymphocyte proliferation; the second domain, which contains concanavalin A motif-, is required for T cell activation9. It can also up regulate natural killer cell activity10. Furthermore, synovial tissues of RA patients contain T-cells, which bear the same T-cell receptors as used by MAM. The mitogen seems to be capable of initiating and exacerbating arthritic changes11, 12. MAM is a zinc-dependent antigen that binds to MHC class II molecules. Zinc induces MHC protein dimerisation.

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