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    The female sex-specific transcript encodes a highly active methyltransferase with an N-terminal truncation compared with somatic Dnmt1. Immunohistochemical analysis of testis detected high levels of nuclear Dnmt1 at all stages of sperm development except in pachytene spermatocytes, which was concurrent with high expression of the sex-specific transcript. Growing oocytes, but not nongrowing oocytes, showed intense Dnmt1 nuclear staining and substantial cytoplasmic staining. Dnmt1 localization became progressively more cytoplasmic during growth, and at the time of ovulation, all Dnmt1 staining was cytoplasmic and was associated with the oocyte cortex. Mature oocytes.

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