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    Gene Structure In their Figure 1, Bigey et al. (2000) showed that the DNMT 1 gene contains at least 37 exons. Bigey et al. (2000) identified 4 clusters of transcription initiation sites, which they called P1 through P4, in DNMT 1. The major cluster, P1, is located within a CG-rich region in exon 1. The minor clusters, P2, P3, and P4, are located within CG-poor regions in exons 2, 3, and 4, respectively. Functional analysis showed that each cluster is associated with independent upstream promoter and enhancer sequences. P2, P3.

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