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Fukuoka JapanSo in the event, the CNS could be exposed to bacterial toxins and generate an immunological response. Many autoimmune diseases involve HLAs. The latter play a key role in antigen presentation to CD4 Th cells. Specific regions of HLA e.g. HLA-C have robust association with MS and Graves disease43. More recently serology and PCR (polymerase chain reaction) have provided ample evidence of Chlamydia pneumoniae.